Background: The role of Epstein-Barr virus (EBV) in the appearance of some sort of B-cell neoplasm such as Burkitt's lymphoma has approximately been proved. With respect to the prevalence of Burkitt's lymphoma in Iran and related topics on treatment and prevention, the present study has assessed the association between the EBV and Burkitt's lymphoma.Materials and methods: It was a descriptive study. Paraffin-embedded blocks of 101 samples with the diagnosis of Burkitt's lymphoma were studied using immunohistochemistry and histochemistry techniques in Kiel University in Germany.Results: Of 101 samples, the diagnosis of Burkitt's lymphoma was confirmed in 65 cases (64.5%), among which 3 cases (4.6%) had been infected by EBV.Conclusion: Since there was a weak association between EBV and Burkitt's lymphoma and also with respect to the prevalence of Burkitt in Iran, other possible etiologic factors should be considered.

Introduction: Burkitt lymphoma (BL) is rare, but an aggressive malignancy. Central nervous system Burkitt lymphoma (CNSBL) is very rare. CNS Burkitt’s lymphoma is treated with high-dose chemotherapy and radiation. Radiotherapy in children younger than three years old may cause major CNS damage.Case report: A three-year-old boy presented with painful proptosis of the left eye. He underwent adenoidectomy 2 months before admitted to our center. Sleep difficulty was not resolved after surgery. Microscopic study of paranasal sinus biopsy and IHC confirmed the diagnosis of Burkitt Lymphoma.Conclusions: Inany patients presenting with painful proptosis, BL should be considered. Adenoid hyperplasia should not be considered as a sole cause of sleep difficulty.

Introduction: Primary gastric lymphoma (PGL) is a rare tumor, whose differential diagnosis may become complicated without precise immunohistochemistry (IHC) and genetic analysis.Case Presentation: A 33-year-old woman presented with gastric cancer and had undergone gastrectomy without precise IHC and staging in another center. Inappropriate IHC after surgery showed diffuse large B-cell lymphoma. After her admission to our center, due to gastrointestinal (GI) symptoms further evaluations were performed, leading to application of chemotherapy and radiotherapy regimens. In the next admissions, involvement of tibia, jaw, and gingiva took place and Burkitt lymphoma was diagnosed with precise IHC panel, which made alteration in the treatment. In the last admission, she expired due to renal failure and tumor lysis syndrome.Conclusions: There was some mismanagement in this case, especially incomplete and inappropriate IHC panel, which led to wrong diagnosis.

An important complication of chemotherapy is thromboembolic events that can occur during treatment course. In this way, Warfarin can be used as an efficient prophylactic agent to prevent these complications. Although bleeding is a common adverse effect of Warfarin, eosinophilia is a rare side effect of this drug. We have reported a 5-year-old boy with Burkitt lymphoma who underwent chemotherapy. In the course of chemotherapy, because of thrombosis of the left jugular vein, we initiated Warfarin as a prophylactic drug for TEE secondary to chemotherapy. Following Warfarin initiation, eosinophilia appeared and subsequent to cessation of drug, eosinophilia disappeared. This case is presented to point out physicians to consider eosinophilia as a rare adverse-effect of Warfarin and monitor blood cell differentiation regularly during the course of treatment with this drug.

Background: Burkitt lymphoma is a common subtype of non-Hodgkin lymphoma in children. It has a rapid and aggressive clinical course with frequent involvement of bone marrow and central nervous system. Systemic chemotherapy is the mainstay of the treatment for this malignancy in children.In this systematic review, we discuss autologous and allogeneic hematopoietic stem cell transplantation (HSCT) and its indications in pediatric patients with Burkitt lymphoma.Methods: The Medline (PubMed) database was searched using all keywords and phrases. The studies were identified by utilizing a combination of MeSH terms, such as Burkitt lymphoma, stem cell transplantation, autologous transplantation and allogeneic transplantation. Articles which were not published as full articles (conference proceedings excluded) were excluded. Relevant articles published during 2000-2015 were included.Results: 13 articles met the inclusion criteria and were discussed.Conclusion: Both autologous and allogeneic HSCT may improve survival in patients with BL. Autologous HSCT is mainly considered for patients with high-risk features of BL at presentation; however, allo-HSCT with non-myeloablative conditioning regimens are preferred for advanced stages and relapsed/refractory disease.

Burkitt lymphoma of stomach is among the most rapidly growing gastric cancersassociated with several gasterointestinal symptoms including hematemesis, anorexia, vomiting and etc. Gastric perforation in patients with Burkitt lymphoma of stomach is a very rare condition especially after chemotherapy. We herein present a 21-year old man who was kwon case of gastric Burkitt lymphoma who had undergone chemotherapy and presented with acute onset gastric pain and tenderness. He was diagnosed to suffer from perforated gastric lymphoma for which laparotomy and total gastrectomy was performed. Treatment was continued by chemotherapy. Closed observation is thus recommended for those patients with gastric Burkitt lymphoma undergoing chemotherapy.

Burkitt’s lymphoma is a lymphatic tumor classified as non-Hodgkin lymphoma with small non cleaved cells. The disease has an incidence of two cases per million patients in North America, and usually present with an intra-abdominal tumor, or enlarged cervical lymph nodes. Massive amounts of peritoneal and plural fluid is rarely seen in these patients. A three year-old girl presented with massive pleural effusion, ascites, mesenteric infiltration, and intraperitoneal mass is discussed in this report. Burkitt's lymphoma is a highly aggressive tumor with a very rapid growth and a variety of different presentations. It is potentially curable, if highly intensive multidrug chemotherapy is used with aggressive central nervous system prophylaxis.

We present a 13. 5 years old boy with chronic intussusception that was misdiagnosed as Crohn disease and received treatment for the wrong diagnosis. Because his condition didn’ t improve, more work-up were performed and the radiologic work-ups revealed the diagnosis of a missed intussusception with fistula. We suggest that prolonged intussusception should be considered in the list of differential diagnosis for the refractory abdominal pain and distention, bloody diarrhea, and radiologist consultancy should be requested, as Crohn disease, infectious gastroenteritis, abdominal malignancies and prolonged intussusception should be carefully investigated and considered in such situations.